| Roanoke to Superior (Colorado) | 1,368.35 mi (2,202.14 km) |
| Roanoke to Superior (Wisconsin) | 898.49 mi (1,445.99 km) |
| Roanoke to Surprise (Arizona) | 1,835.92 mi (2,954.63 km) |
| Roanoke to Susanville (California) | 2,179.08 mi (3,506.90 km) |
| Roanoke to Sussex (Wisconsin) | 594.34 mi (956.50 km) |
| Roanoke to Suwanee (Georgia) | 320.83 mi (516.33 km) |
| Roanoke to Swansea (Illinois) | 553.34 mi (890.51 km) |
| Roanoke to Sweetwater (Florida) | 794.95 mi (1,279.35 km) |
| Roanoke to Sweetwater (Texas) | 1,203.20 mi (1,936.36 km) |
| Roanoke to Sycamore (Illinois) | 566.71 mi (912.03 km) |
| Roanoke to Sylacauga (Alabama) | 454.55 mi (731.53 km) |
| Roanoke to Sylvania (Ohio) | 365.63 mi (588.42 km) |
| Roanoke to Syosset (New York) | 423.77 mi (681.99 km) |
| Roanoke to Syracuse (New York) | 446.05 mi (717.85 km) |
| Roanoke to Syracuse (Utah) | 1,729.83 mi (2,783.90 km) |
