| Roanoke to Storm Lake (Iowa) | 886.31 mi (1,426.37 km) |
| Roanoke to Storrs (Connecticut) | 515.94 mi (830.32 km) |
| Roanoke to Stoughton (Wisconsin) | 625.33 mi (1,006.38 km) |
| Roanoke to Stow (Ohio) | 280.66 mi (451.69 km) |
| Roanoke to Streamwood (Illinois) | 546.00 mi (878.70 km) |
| Roanoke to Streator (Illinois) | 543.88 mi (875.30 km) |
| Roanoke to Streetsboro (Ohio) | 283.56 mi (456.35 km) |
| Roanoke to Strongsville (Ohio) | 296.17 mi (476.64 km) |
| Roanoke to Stuart (Florida) | 696.84 mi (1,121.46 km) |
| Roanoke to Stuarts Draft (Virginia) | 71.86 mi (115.65 km) |
| Roanoke to Sturgis (Michigan) | 426.67 mi (686.66 km) |
| Roanoke to Suamico (Wisconsin) | 660.71 mi (1,063.31 km) |
| Roanoke to Sudley (Virginia) | 169.77 mi (273.22 km) |
| Roanoke to Suffern (New York) | 408.73 mi (657.79 km) |
| Roanoke to Suffolk (Virginia) | 187.51 mi (301.76 km) |
