| Roanoke to Stephenville (Texas) | 1,092.10 mi (1,757.57 km) |
| Roanoke to Sterling (Colorado) | 1,265.78 mi (2,037.07 km) |
| Roanoke to Sterling (Illinois) | 605.06 mi (973.75 km) |
| Roanoke to Sterling (Virginia) | 182.96 mi (294.45 km) |
| Roanoke to Sterling Heights (Michigan) | 400.82 mi (645.06 km) |
| Roanoke to Steubenville (Ohio) | 216.52 mi (348.46 km) |
| Roanoke to Stevens Point (Wisconsin) | 707.28 mi (1,138.25 km) |
| Roanoke to Stevenson Ranch (California) | 2,158.08 mi (3,473.10 km) |
| Roanoke to Stillwater (Minnesota) | 856.79 mi (1,378.87 km) |
| Roanoke to Stillwater (Oklahoma) | 950.12 mi (1,529.08 km) |
| Roanoke to Stockbridge (Georgia) | 353.63 mi (569.11 km) |
| Roanoke to Stockton (California) | 2,244.50 mi (3,612.17 km) |
| Roanoke to Stone Ridge (Virginia) | 173.40 mi (279.06 km) |
| Roanoke to Stonecrest (Georgia) | 341.91 mi (550.26 km) |
| Roanoke to Stony Brook (New York) | 443.60 mi (713.91 km) |
