| Roanoke to St. Simons (Georgia) | 429.34 mi (690.95 km) |
| Roanoke to Stafford (Texas) | 1,041.47 mi (1,676.09 km) |
| Roanoke to Stallings (North Carolina) | 154.93 mi (249.34 km) |
| Roanoke to Stamford (Connecticut) | 432.58 mi (696.17 km) |
| Roanoke to Stanford (California) | 2,298.40 mi (3,698.91 km) |
| Roanoke to Stanton (California) | 2,137.51 mi (3,440.00 km) |
| Roanoke to Star (Idaho) | 1,953.54 mi (3,143.92 km) |
| Roanoke to Starkville (Mississippi) | 564.81 mi (908.98 km) |
| Roanoke to State College (Pennsylvania) | 267.59 mi (430.64 km) |
| Roanoke to Staten Island (New York) | 386.65 mi (622.25 km) |
| Roanoke to Statesboro (Georgia) | 349.96 mi (563.21 km) |
| Roanoke to Statesville (North Carolina) | 115.02 mi (185.11 km) |
| Roanoke to Staunton (Virginia) | 78.15 mi (125.77 km) |
| Roanoke to Steamboat Springs (Colorado) | 1,456.12 mi (2,343.39 km) |
| Roanoke to Steiner Ranch (Texas) | 1,132.52 mi (1,822.62 km) |
