| Roanoke to Spout Springs (North Carolina) | 147.87 mi (237.98 km) |
| Roanoke to Spring (Texas) | 1,015.62 mi (1,634.48 km) |
| Roanoke to Spring Creek (Nevada) | 1,915.08 mi (3,082.02 km) |
| Roanoke to Spring Hill (Florida) | 625.90 mi (1,007.29 km) |
| Roanoke to Spring Hill (Tennessee) | 400.34 mi (644.28 km) |
| Roanoke to Spring Lake (North Carolina) | 154.30 mi (248.33 km) |
| Roanoke to Spring Valley (California) | 2,104.93 mi (3,387.55 km) |
| Roanoke to Spring Valley (Nevada) | 1,946.49 mi (3,132.57 km) |
| Roanoke to Spring Valley (New York) | 412.61 mi (664.04 km) |
| Roanoke to Springboro (Ohio) | 280.09 mi (450.76 km) |
| Roanoke to Springdale (Arkansas) | 789.09 mi (1,269.92 km) |
| Roanoke to Springdale (New Jersey) | 323.57 mi (520.74 km) |
| Roanoke to Springdale (Ohio) | 281.67 mi (453.31 km) |
| Roanoke to Springfield (Illinois) | 551.33 mi (887.28 km) |
| Roanoke to Springfield (Massachusetts) | 516.59 mi (831.37 km) |
