| Roanoke to Southern Pines (North Carolina) | 147.39 mi (237.20 km) |
| Roanoke to Southfield (Michigan) | 399.47 mi (642.89 km) |
| Roanoke to Southgate (Michigan) | 381.52 mi (614.00 km) |
| Roanoke to Southlake (Texas) | 1,014.84 mi (1,633.23 km) |
| Roanoke to Spanaway (Washington) | 2,246.48 mi (3,615.36 km) |
| Roanoke to Spanish Fork (Utah) | 1,710.59 mi (2,752.93 km) |
| Roanoke to Spanish Lake (Missouri) | 567.15 mi (912.73 km) |
| Roanoke to Spanish Springs (Nevada) | 2,137.05 mi (3,439.25 km) |
| Roanoke to Sparks (Nevada) | 2,140.36 mi (3,444.58 km) |
| Roanoke to Spartanburg (South Carolina) | 195.10 mi (313.98 km) |
| Roanoke to Spearfish (South Dakota) | 1,336.06 mi (2,150.18 km) |
| Roanoke to Speedway (Indiana) | 381.66 mi (614.23 km) |
| Roanoke to Spencer (Iowa) | 896.59 mi (1,442.91 km) |
| Roanoke to Spokane (Washington) | 2,016.75 mi (3,245.64 km) |
| Roanoke to Spokane Valley (Washington) | 2,007.55 mi (3,230.84 km) |
