| Roanoke to South Plainfield (New Jersey) | 374.88 mi (603.32 km) |
| Roanoke to South Portland (Maine) | 670.77 mi (1,079.50 km) |
| Roanoke to South Riding (Virginia) | 174.38 mi (280.63 km) |
| Roanoke to South River (New Jersey) | 371.35 mi (597.63 km) |
| Roanoke to South Salt Lake (Utah) | 1,721.90 mi (2,771.14 km) |
| Roanoke to South San Francisco (California) | 2,308.37 mi (3,714.96 km) |
| Roanoke to South San Jose Hills (California) | 2,128.27 mi (3,425.12 km) |
| Roanoke to South Sioux City (Nebraska) | 941.22 mi (1,514.74 km) |
| Roanoke to South St. Paul (Minnesota) | 858.80 mi (1,382.11 km) |
| Roanoke to South Valley (New Mexico) | 1,494.30 mi (2,404.84 km) |
| Roanoke to South Venice (Florida) | 721.48 mi (1,161.12 km) |
| Roanoke to South Whittier (California) | 2,136.82 mi (3,438.88 km) |
| Roanoke to South Yarmouth (Massachusetts) | 601.83 mi (968.55 km) |
| Roanoke to Southaven (Mississippi) | 581.62 mi (936.03 km) |
| Roanoke to Southchase (Florida) | 620.45 mi (998.51 km) |
