| Roanoke to Somersworth (New Hampshire) | 631.16 mi (1,015.75 km) |
| Roanoke to Somerton (Arizona) | 1,982.77 mi (3,190.97 km) |
| Roanoke to Somerville (Massachusetts) | 587.32 mi (945.20 km) |
| Roanoke to Somerville (New Jersey) | 366.45 mi (589.74 km) |
| Roanoke to Sonoma (California) | 2,301.20 mi (3,703.42 km) |
| Roanoke to Soquel (California) | 2,293.42 mi (3,690.90 km) |
| Roanoke to South Bend (Indiana) | 453.25 mi (729.43 km) |
| Roanoke to South Bradenton (Florida) | 695.29 mi (1,118.96 km) |
| Roanoke to South Burlington (Vermont) | 608.03 mi (978.53 km) |
| Roanoke to South Charleston (West Virginia) | 120.86 mi (194.51 km) |
| Roanoke to South Daytona (Florida) | 563.79 mi (907.33 km) |
| Roanoke to South El Monte (California) | 2,135.40 mi (3,436.59 km) |
| Roanoke to South Elgin (Illinois) | 550.62 mi (886.14 km) |
| Roanoke to South Euclid (Ohio) | 305.01 mi (490.86 km) |
| Roanoke to South Farmingdale (New York) | 422.52 mi (679.99 km) |
