| Roanoke to Smyrna (Delaware) | 273.87 mi (440.76 km) |
| Roanoke to Smyrna (Georgia) | 348.22 mi (560.41 km) |
| Roanoke to Smyrna (Tennessee) | 375.21 mi (603.85 km) |
| Roanoke to Snellville (Georgia) | 327.97 mi (527.82 km) |
| Roanoke to Snoqualmie (Washington) | 2,220.51 mi (3,573.56 km) |
| Roanoke to Snyder (Texas) | 1,224.34 mi (1,970.39 km) |
| Roanoke to Socastee (South Carolina) | 253.82 mi (408.49 km) |
| Roanoke to Socorro (Texas) | 1,542.72 mi (2,482.77 km) |
| Roanoke to Soddy-Daisy (Tennessee) | 322.31 mi (518.72 km) |
| Roanoke to Solana Beach (California) | 2,114.46 mi (3,402.90 km) |
| Roanoke to Soledad (California) | 2,270.00 mi (3,653.21 km) |
| Roanoke to Solon (Ohio) | 294.66 mi (474.21 km) |
| Roanoke to Somers Point (New Jersey) | 322.47 mi (518.97 km) |
| Roanoke to Somerset (Kentucky) | 256.46 mi (412.73 km) |
| Roanoke to Somerset (New Jersey) | 368.55 mi (593.12 km) |
