| Roanoke to Silver Firs (Washington) | 2,236.11 mi (3,598.66 km) |
| Roanoke to Silver Spring (Maryland) | 199.16 mi (320.52 km) |
| Roanoke to Silver Springs Shores (Florida) | 576.56 mi (927.88 km) |
| Roanoke to Silverdale (Washington) | 2,260.13 mi (3,637.34 km) |
| Roanoke to Silverton (Oregon) | 2,263.34 mi (3,642.49 km) |
| Roanoke to Simi Valley (California) | 2,169.32 mi (3,491.18 km) |
| Roanoke to Simpsonville (South Carolina) | 218.04 mi (350.89 km) |
| Roanoke to Sioux City (Iowa) | 940.79 mi (1,514.06 km) |
| Roanoke to Sioux Falls (South Dakota) | 980.31 mi (1,577.66 km) |
| Roanoke to Skokie (Illinois) | 528.20 mi (850.05 km) |
| Roanoke to Sleepy Hollow (New York) | 418.99 mi (674.30 km) |
| Roanoke to Slidell (Louisiana) | 741.88 mi (1,193.95 km) |
| Roanoke to Smithfield (North Carolina) | 151.25 mi (243.42 km) |
| Roanoke to Smithfield (Utah) | 1,716.37 mi (2,762.23 km) |
| Roanoke to Smithville (Missouri) | 804.57 mi (1,294.83 km) |
