| Roanoke to Shoreview (Minnesota) | 870.15 mi (1,400.37 km) |
| Roanoke to Shorewood (Illinois) | 528.86 mi (851.11 km) |
| Roanoke to Shorewood (Wisconsin) | 579.53 mi (932.66 km) |
| Roanoke to Short Hills (New Jersey) | 385.26 mi (620.02 km) |
| Roanoke to Short Pump (Virginia) | 130.82 mi (210.54 km) |
| Roanoke to Show Low (Arizona) | 1,691.86 mi (2,722.79 km) |
| Roanoke to Shreveport (Louisiana) | 850.88 mi (1,369.36 km) |
| Roanoke to Sicklerville (New Jersey) | 317.87 mi (511.57 km) |
| Roanoke to Sidney (Ohio) | 307.58 mi (495.00 km) |
| Roanoke to Sierra Madre (California) | 2,133.09 mi (3,432.88 km) |
| Roanoke to Sierra Vista (Arizona) | 1,766.61 mi (2,843.08 km) |
| Roanoke to Sierra Vista Southeast (Arizona) | 1,763.95 mi (2,838.80 km) |
| Roanoke to Signal Hill (California) | 2,147.02 mi (3,455.29 km) |
| Roanoke to Sikeston (Missouri) | 531.26 mi (854.97 km) |
| Roanoke to Siloam Springs (Arkansas) | 809.72 mi (1,303.12 km) |
