| Roanoke to Shelton (Connecticut) | 458.47 mi (737.84 km) |
| Roanoke to Shelton (Washington) | 2,279.07 mi (3,667.82 km) |
| Roanoke to Shenandoah (Louisiana) | 791.15 mi (1,273.23 km) |
| Roanoke to Shepherdsville (Kentucky) | 317.91 mi (511.63 km) |
| Roanoke to Sheridan (Wyoming) | 1,491.79 mi (2,400.80 km) |
| Roanoke to Sherman (Texas) | 969.77 mi (1,560.69 km) |
| Roanoke to Sherrelwood (Colorado) | 1,360.06 mi (2,188.80 km) |
| Roanoke to Sherwood (Arkansas) | 703.60 mi (1,132.33 km) |
| Roanoke to Sherwood (Oregon) | 2,265.75 mi (3,646.37 km) |
| Roanoke to Shiloh (Illinois) | 549.61 mi (884.51 km) |
| Roanoke to Shiloh (Ohio) | 289.88 mi (466.52 km) |
| Roanoke to Shiloh (Pennsylvania) | 252.69 mi (406.67 km) |
| Roanoke to Shirley (New York) | 450.88 mi (725.62 km) |
| Roanoke to Shively (Kentucky) | 326.12 mi (524.84 km) |
| Roanoke to Shoreline (Washington) | 2,244.64 mi (3,612.40 km) |
