| Roanoke to Seymour (Tennessee) | 232.40 mi (374.01 km) |
| Roanoke to Shady Hills (Florida) | 631.22 mi (1,015.85 km) |
| Roanoke to Shafter (California) | 2,170.89 mi (3,493.71 km) |
| Roanoke to Shaker Heights (Ohio) | 302.10 mi (486.18 km) |
| Roanoke to Shakopee (Minnesota) | 872.64 mi (1,404.38 km) |
| Roanoke to Sharon (Pennsylvania) | 274.83 mi (442.29 km) |
| Roanoke to Sharonville (Ohio) | 278.16 mi (447.65 km) |
| Roanoke to Shasta Lake (California) | 2,268.39 mi (3,650.62 km) |
| Roanoke to Shawnee (Kansas) | 814.81 mi (1,311.31 km) |
| Roanoke to Shawnee (Oklahoma) | 954.78 mi (1,536.57 km) |
| Roanoke to Sheboygan (Wisconsin) | 604.49 mi (972.84 km) |
| Roanoke to Shelby (North Carolina) | 163.34 mi (262.87 km) |
| Roanoke to Shelbyville (Indiana) | 351.54 mi (565.74 km) |
| Roanoke to Shelbyville (Kentucky) | 295.00 mi (474.76 km) |
| Roanoke to Shelbyville (Tennessee) | 381.44 mi (613.87 km) |
