| Roanoke to Security-Widefield (Colorado) | 1,347.34 mi (2,168.33 km) |
| Roanoke to Sedalia (Missouri) | 728.94 mi (1,173.11 km) |
| Roanoke to Sedro-Woolley (Washington) | 2,242.84 mi (3,609.50 km) |
| Roanoke to Seguin (Texas) | 1,163.68 mi (1,872.75 km) |
| Roanoke to Selden (New York) | 445.94 mi (717.67 km) |
| Roanoke to Selma (Alabama) | 522.98 mi (841.65 km) |
| Roanoke to Selma (California) | 2,174.67 mi (3,499.80 km) |
| Roanoke to Selma (Texas) | 1,181.43 mi (1,901.33 km) |
| Roanoke to Seminole (Florida) | 672.24 mi (1,081.87 km) |
| Roanoke to Seven Hills (Ohio) | 297.85 mi (479.34 km) |
| Roanoke to Seven Oaks (South Carolina) | 232.94 mi (374.88 km) |
| Roanoke to Severn (Maryland) | 218.69 mi (351.95 km) |
| Roanoke to Severna Park (Maryland) | 222.46 mi (358.01 km) |
| Roanoke to Sevierville (Tennessee) | 222.13 mi (357.48 km) |
| Roanoke to Seymour (Indiana) | 342.45 mi (551.11 km) |
