| Roanoke to Scottsboro (Alabama) | 386.11 mi (621.39 km) |
| Roanoke to Scottsdale (Arizona) | 1,803.58 mi (2,902.59 km) |
| Roanoke to Scranton (Pennsylvania) | 365.81 mi (588.71 km) |
| Roanoke to Seabrook (Maryland) | 205.79 mi (331.18 km) |
| Roanoke to Seabrook (Texas) | 1,016.88 mi (1,636.51 km) |
| Roanoke to Seaford (New York) | 418.71 mi (673.85 km) |
| Roanoke to Seagoville (Texas) | 990.47 mi (1,594.01 km) |
| Roanoke to Seal Beach (California) | 2,142.74 mi (3,448.41 km) |
| Roanoke to Searcy (Arkansas) | 670.56 mi (1,079.17 km) |
| Roanoke to Seaside (California) | 2,292.69 mi (3,689.72 km) |
| Roanoke to SeaTac (Washington) | 2,241.56 mi (3,607.44 km) |
| Roanoke to Seattle (Washington) | 2,243.32 mi (3,610.28 km) |
| Roanoke to Sebastian (Florida) | 656.84 mi (1,057.08 km) |
| Roanoke to Sebring (Florida) | 682.78 mi (1,098.83 km) |
| Roanoke to Secaucus (New Jersey) | 398.06 mi (640.62 km) |
