| Roanoke to Savannah (Georgia) | 369.33 mi (594.38 km) |
| Roanoke to Sayreville (New Jersey) | 374.51 mi (602.71 km) |
| Roanoke to Sayville (New York) | 439.84 mi (707.86 km) |
| Roanoke to Scaggsville (Maryland) | 210.73 mi (339.14 km) |
| Roanoke to Scarsdale (New York) | 418.73 mi (673.89 km) |
| Roanoke to Schaumburg (Illinois) | 542.40 mi (872.91 km) |
| Roanoke to Schenectady (New York) | 497.14 mi (800.07 km) |
| Roanoke to Schererville (Indiana) | 494.00 mi (795.02 km) |
| Roanoke to Schertz (Texas) | 1,179.16 mi (1,897.67 km) |
| Roanoke to Schiller Park (Illinois) | 530.51 mi (853.77 km) |
| Roanoke to Schofield Barracks (Hawaii) | 4,698.61 mi (7,561.68 km) |
| Roanoke to Scotchtown (New York) | 416.12 mi (669.68 km) |
| Roanoke to Scottdale (Georgia) | 341.28 mi (549.23 km) |
| Roanoke to Scotts Valley (California) | 2,295.89 mi (3,694.88 km) |
| Roanoke to Scottsbluff (Nebraska) | 1,297.04 mi (2,087.38 km) |
