| Roanoke to Santa Rosa (California) | 2,312.12 mi (3,721.00 km) |
| Roanoke to Santaquin (Utah) | 1,719.35 mi (2,767.02 km) |
| Roanoke to Santee (California) | 2,102.61 mi (3,383.83 km) |
| Roanoke to Sapulpa (Oklahoma) | 898.07 mi (1,445.31 km) |
| Roanoke to Saraland (Alabama) | 643.40 mi (1,035.45 km) |
| Roanoke to Sarasota (Florida) | 703.08 mi (1,131.50 km) |
| Roanoke to Sarasota Springs (Florida) | 704.27 mi (1,133.41 km) |
| Roanoke to Saratoga (California) | 2,293.29 mi (3,690.69 km) |
| Roanoke to Saratoga Springs (New York) | 515.87 mi (830.22 km) |
| Roanoke to Saratoga Springs (Utah) | 1,724.07 mi (2,774.62 km) |
| Roanoke to Sartell (Minnesota) | 934.45 mi (1,503.86 km) |
| Roanoke to Satellite Beach (Florida) | 629.88 mi (1,013.69 km) |
| Roanoke to Sauk Rapids (Minnesota) | 930.97 mi (1,498.25 km) |
| Roanoke to Sault Ste. Marie (Michigan) | 674.92 mi (1,086.18 km) |
| Roanoke to Savage (Minnesota) | 867.16 mi (1,395.55 km) |
