| Roanoke to Sanford (Maine) | 643.51 mi (1,035.63 km) |
| Roanoke to Sanford (North Carolina) | 131.15 mi (211.07 km) |
| Roanoke to Sanger (California) | 2,169.58 mi (3,491.59 km) |
| Roanoke to Santa Ana (California) | 2,132.73 mi (3,432.29 km) |
| Roanoke to Santa Barbara (California) | 2,219.09 mi (3,571.29 km) |
| Roanoke to Santa Clara (California) | 2,288.67 mi (3,683.26 km) |
| Roanoke to Santa Clara (Oregon) | 2,283.35 mi (3,674.70 km) |
| Roanoke to Santa Clarita (California) | 2,152.51 mi (3,464.13 km) |
| Roanoke to Santa Cruz (California) | 2,298.35 mi (3,698.84 km) |
| Roanoke to Santa Fe (New Mexico) | 1,445.69 mi (2,326.62 km) |
| Roanoke to Santa Fe (Texas) | 1,028.15 mi (1,654.64 km) |
| Roanoke to Santa Fe Springs (California) | 2,138.55 mi (3,441.66 km) |
| Roanoke to Santa Maria (California) | 2,248.57 mi (3,618.73 km) |
| Roanoke to Santa Monica (California) | 2,159.59 mi (3,475.52 km) |
| Roanoke to Santa Paula (California) | 2,184.85 mi (3,516.17 km) |
