| Roanoke to San Luis Obispo (California) | 2,254.51 mi (3,628.28 km) |
| Roanoke to San Marcos (California) | 2,106.80 mi (3,390.57 km) |
| Roanoke to San Marcos (Texas) | 1,151.77 mi (1,853.60 km) |
| Roanoke to San Marino (California) | 2,137.46 mi (3,439.91 km) |
| Roanoke to San Mateo (California) | 2,304.18 mi (3,708.22 km) |
| Roanoke to San Pablo (California) | 2,299.66 mi (3,700.95 km) |
| Roanoke to San Rafael (California) | 2,308.81 mi (3,715.68 km) |
| Roanoke to San Ramon (California) | 2,280.96 mi (3,670.85 km) |
| Roanoke to San Tan Valley (Arizona) | 1,797.59 mi (2,892.94 km) |
| Roanoke to Sand Springs (Oklahoma) | 898.08 mi (1,445.32 km) |
| Roanoke to Sandusky (Ohio) | 323.12 mi (520.01 km) |
| Roanoke to Sandy (Oregon) | 2,237.90 mi (3,601.56 km) |
| Roanoke to Sandy (Utah) | 1,719.83 mi (2,767.79 km) |
| Roanoke to Sandy Springs (Georgia) | 338.66 mi (545.03 km) |
| Roanoke to Sanford (Florida) | 591.48 mi (951.90 km) |
