| Roanoke to Salisbury (New York) | 418.56 mi (673.61 km) |
| Roanoke to Salisbury (North Carolina) | 115.29 mi (185.53 km) |
| Roanoke to Salmon Creek (Washington) | 2,256.73 mi (3,631.85 km) |
| Roanoke to Salt Lake City (Utah) | 1,723.39 mi (2,773.53 km) |
| Roanoke to Sammamish (Washington) | 2,230.10 mi (3,589.00 km) |
| Roanoke to San Angelo (Texas) | 1,233.37 mi (1,984.92 km) |
| Roanoke to San Anselmo (California) | 2,311.48 mi (3,719.97 km) |
| Roanoke to San Antonio (Texas) | 1,196.68 mi (1,925.87 km) |
| Roanoke to San Benito (Texas) | 1,290.14 mi (2,076.28 km) |
| Roanoke to San Bernardino (California) | 2,092.27 mi (3,367.19 km) |
| Roanoke to San Bruno (California) | 2,309.42 mi (3,716.65 km) |
| Roanoke to San Buenaventura (California) | 2,195.51 mi (3,533.34 km) |
| Roanoke to San Carlos (California) | 2,302.63 mi (3,705.73 km) |
| Roanoke to San Carlos Park (Florida) | 754.24 mi (1,213.83 km) |
| Roanoke to San Clemente (California) | 2,123.90 mi (3,418.09 km) |
