| Roanoke to Saddlebrooke (Arizona) | 1,773.46 mi (2,854.11 km) |
| Roanoke to Safety Harbor (Florida) | 659.95 mi (1,062.09 km) |
| Roanoke to Saginaw (Michigan) | 473.39 mi (761.85 km) |
| Roanoke to Saginaw (Texas) | 1,028.71 mi (1,655.55 km) |
| Roanoke to Sahuarita (Arizona) | 1,793.19 mi (2,885.86 km) |
| Roanoke to Saks (Alabama) | 413.03 mi (664.71 km) |
| Roanoke to Salem (Massachusetts) | 600.46 mi (966.35 km) |
| Roanoke to Salem (Ohio) | 255.07 mi (410.50 km) |
| Roanoke to Salem (Oregon) | 2,275.41 mi (3,661.92 km) |
| Roanoke to Salem (Virginia) | 5.38 mi (8.66 km) |
| Roanoke to Salem Lakes (Wisconsin) | 564.85 mi (909.05 km) |
| Roanoke to Salida (California) | 2,236.24 mi (3,598.89 km) |
| Roanoke to Salina (Kansas) | 965.02 mi (1,553.05 km) |
| Roanoke to Salinas (California) | 2,281.47 mi (3,671.66 km) |
| Roanoke to Salisbury (Maryland) | 250.30 mi (402.82 km) |
