| Roanoke to Reedley (California) | 2,165.21 mi (3,484.57 km) |
| Roanoke to Reidsville (North Carolina) | 66.90 mi (107.67 km) |
| Roanoke to Reisterstown (Maryland) | 227.18 mi (365.62 km) |
| Roanoke to Rendon (Texas) | 1,029.34 mi (1,656.56 km) |
| Roanoke to Reno (Nevada) | 2,147.57 mi (3,456.18 km) |
| Roanoke to Renton (Washington) | 2,236.68 mi (3,599.59 km) |
| Roanoke to Republic (Missouri) | 741.54 mi (1,193.39 km) |
| Roanoke to Reston (Virginia) | 183.00 mi (294.51 km) |
| Roanoke to Revere (Massachusetts) | 592.53 mi (953.58 km) |
| Roanoke to Rexburg (Idaho) | 1,719.60 mi (2,767.44 km) |
| Roanoke to Reynoldsburg (Ohio) | 240.26 mi (386.66 km) |
| Roanoke to Rialto (California) | 2,097.95 mi (3,376.32 km) |
| Roanoke to Richardson (Texas) | 990.70 mi (1,594.38 km) |
| Roanoke to Richfield (Minnesota) | 868.32 mi (1,397.42 km) |
| Roanoke to Richfield (Wisconsin) | 599.65 mi (965.04 km) |
