| Roanoke to Owosso (Michigan) | 453.36 mi (729.60 km) |
| Roanoke to Oxford (Alabama) | 418.68 mi (673.80 km) |
| Roanoke to Oxford (Mississippi) | 572.70 mi (921.68 km) |
| Roanoke to Oxford (Ohio) | 301.39 mi (485.05 km) |
| Roanoke to Oxnard (California) | 2,194.36 mi (3,531.48 km) |
| Roanoke to Oxon Hill (Maryland) | 193.06 mi (310.70 km) |
| Roanoke to Ozark (Alabama) | 516.89 mi (831.85 km) |
| Roanoke to Ozark (Missouri) | 729.64 mi (1,174.24 km) |
| Roanoke to Pace (Florida) | 617.99 mi (994.56 km) |
| Roanoke to Pacific Grove (California) | 2,298.45 mi (3,699.00 km) |
| Roanoke to Pacifica (California) | 2,312.14 mi (3,721.03 km) |
| Roanoke to Paducah (Kentucky) | 478.23 mi (769.64 km) |
| Roanoke to Pahrump (Nevada) | 1,984.36 mi (3,193.52 km) |
| Roanoke to Painesville (Ohio) | 314.81 mi (506.64 km) |
| Roanoke to Palatine (Illinois) | 544.13 mi (875.70 km) |
