| Roanoke to Oskaloosa (Iowa) | 731.83 mi (1,177.77 km) |
| Roanoke to Oswego (Illinois) | 540.24 mi (869.43 km) |
| Roanoke to Oswego (New York) | 463.62 mi (746.13 km) |
| Roanoke to Otsego (Minnesota) | 896.75 mi (1,443.18 km) |
| Roanoke to Ottawa (Illinois) | 550.99 mi (886.73 km) |
| Roanoke to Ottawa (Kansas) | 838.01 mi (1,348.65 km) |
| Roanoke to Ottumwa (Iowa) | 715.13 mi (1,150.89 km) |
| Roanoke to Overland (Missouri) | 575.00 mi (925.37 km) |
| Roanoke to Overland Park (Kansas) | 807.79 mi (1,300.02 km) |
| Roanoke to Overlea (Maryland) | 235.66 mi (379.26 km) |
| Roanoke to Oviedo (Florida) | 599.85 mi (965.36 km) |
| Roanoke to Owasso (Oklahoma) | 879.99 mi (1,416.21 km) |
| Roanoke to Owatonna (Minnesota) | 838.11 mi (1,348.82 km) |
| Roanoke to Owensboro (Kentucky) | 393.63 mi (633.49 km) |
| Roanoke to Owings Mills (Maryland) | 226.18 mi (364.00 km) |
