| Roanoke to Orangeburg (South Carolina) | 266.53 mi (428.93 km) |
| Roanoke to Orangevale (California) | 2,230.13 mi (3,589.05 km) |
| Roanoke to Orchards (Washington) | 2,250.34 mi (3,621.57 km) |
| Roanoke to Orcutt (California) | 2,248.67 mi (3,618.89 km) |
| Roanoke to Oregon (Ohio) | 354.42 mi (570.38 km) |
| Roanoke to Oregon (Wisconsin) | 632.29 mi (1,017.57 km) |
| Roanoke to Oregon City (Oregon) | 2,253.62 mi (3,626.85 km) |
| Roanoke to Orem (Utah) | 1,712.90 mi (2,756.64 km) |
| Roanoke to Orinda (California) | 2,292.15 mi (3,688.86 km) |
| Roanoke to Orland Park (Illinois) | 516.67 mi (831.50 km) |
| Roanoke to Orlando (Florida) | 613.32 mi (987.05 km) |
| Roanoke to Ormond Beach (Florida) | 555.29 mi (893.65 km) |
| Roanoke to Oro Valley (Arizona) | 1,782.25 mi (2,868.25 km) |
| Roanoke to Oroville (California) | 2,238.36 mi (3,602.30 km) |
| Roanoke to Oshkosh (Wisconsin) | 647.79 mi (1,042.52 km) |
