| Roanoke to Olympia (Washington) | 2,268.60 mi (3,650.95 km) |
| Roanoke to Olympia Heights (Florida) | 798.65 mi (1,285.30 km) |
| Roanoke to Omaha (Nebraska) | 902.26 mi (1,452.05 km) |
| Roanoke to On Top of the World Designated Place (Florida) | 580.45 mi (934.14 km) |
| Roanoke to Onalaska (Wisconsin) | 745.19 mi (1,199.26 km) |
| Roanoke to Oneida (New York) | 460.20 mi (740.63 km) |
| Roanoke to Oneonta (New York) | 441.65 mi (710.77 km) |
| Roanoke to Ontario (California) | 2,111.41 mi (3,397.99 km) |
| Roanoke to Ontario (Oregon) | 1,977.91 mi (3,183.15 km) |
| Roanoke to Opa-locka (Florida) | 786.39 mi (1,265.58 km) |
| Roanoke to Opelika (Alabama) | 442.45 mi (712.05 km) |
| Roanoke to Opelousas (Louisiana) | 836.19 mi (1,345.71 km) |
| Roanoke to Orange (California) | 2,128.04 mi (3,424.75 km) |
| Roanoke to Orange (Texas) | 933.32 mi (1,502.04 km) |
| Roanoke to Orange City (Florida) | 581.59 mi (935.98 km) |
