| Roanoke to Odenton (Maryland) | 216.06 mi (347.72 km) |
| Roanoke to Odessa (Texas) | 1,323.39 mi (2,129.79 km) |
| Roanoke to Ogden (Utah) | 1,724.27 mi (2,774.94 km) |
| Roanoke to Oildale (California) | 2,162.52 mi (3,480.23 km) |
| Roanoke to Ojus (Florida) | 782.38 mi (1,259.12 km) |
| Roanoke to Okemos (Michigan) | 442.83 mi (712.66 km) |
| Roanoke to Oklahoma City (Oklahoma) | 983.18 mi (1,582.28 km) |
| Roanoke to Okmulgee (Oklahoma) | 898.27 mi (1,445.62 km) |
| Roanoke to Olathe (Kansas) | 814.92 mi (1,311.49 km) |
| Roanoke to Old Jamestown (Missouri) | 571.72 mi (920.09 km) |
| Roanoke to Oldsmar (Florida) | 656.71 mi (1,056.88 km) |
| Roanoke to Olean (New York) | 341.64 mi (549.82 km) |
| Roanoke to Olive Branch (Mississippi) | 574.36 mi (924.34 km) |
| Roanoke to Olivehurst (California) | 2,242.99 mi (3,609.74 km) |
| Roanoke to Olney (Maryland) | 203.00 mi (326.69 km) |
