| Roanoke to Oakleaf Plantation (Florida) | 502.88 mi (809.30 km) |
| Roanoke to Oakley (California) | 2,264.75 mi (3,644.76 km) |
| Roanoke to Oakton (Virginia) | 182.33 mi (293.43 km) |
| Roanoke to Oakville (Missouri) | 570.64 mi (918.36 km) |
| Roanoke to Oatfield (Oregon) | 2,253.62 mi (3,626.85 km) |
| Roanoke to Ocala (Florida) | 573.81 mi (923.46 km) |
| Roanoke to Ocean Acres (New Jersey) | 350.92 mi (564.76 km) |
| Roanoke to Ocean City (New Jersey) | 321.34 mi (517.14 km) |
| Roanoke to Ocean Pines (Maryland) | 273.32 mi (439.87 km) |
| Roanoke to Ocean Pointe (Hawaii) | 4,703.56 mi (7,569.65 km) |
| Roanoke to Ocean Springs (Mississippi) | 693.62 mi (1,116.27 km) |
| Roanoke to Oceanside (California) | 2,112.20 mi (3,399.26 km) |
| Roanoke to Oceanside (New York) | 411.02 mi (661.47 km) |
| Roanoke to Ocoee (Florida) | 607.91 mi (978.33 km) |
| Roanoke to Oconomowoc (Wisconsin) | 603.39 mi (971.07 km) |
