| Roanoke to Mattoon (Illinois) | 479.67 mi (771.95 km) |
| Roanoke to Mauldin (South Carolina) | 216.59 mi (348.58 km) |
| Roanoke to Maumee (Ohio) | 356.31 mi (573.43 km) |
| Roanoke to Maumelle (Arkansas) | 714.24 mi (1,149.46 km) |
| Roanoke to Mayagüez (Puerto Rico) | 1,530.05 mi (2,462.37 km) |
| Roanoke to Mayfield Heights (Ohio) | 303.55 mi (488.52 km) |
| Roanoke to Mays Chapel (Maryland) | 232.95 mi (374.90 km) |
| Roanoke to Maywood (California) | 2,144.26 mi (3,450.85 km) |
| Roanoke to Maywood (Illinois) | 526.34 mi (847.07 km) |
| Roanoke to McAlester (Oklahoma) | 896.61 mi (1,442.96 km) |
| Roanoke to McAllen (Texas) | 1,314.29 mi (2,115.14 km) |
| Roanoke to McCalla (Alabama) | 484.07 mi (779.03 km) |
| Roanoke to McComb (Mississippi) | 730.17 mi (1,175.10 km) |
| Roanoke to McDonough (Georgia) | 355.10 mi (571.48 km) |
| Roanoke to McFarland (California) | 2,169.53 mi (3,491.52 km) |
