| Roanoke to Lovington (New Mexico) | 1,351.36 mi (2,174.80 km) |
| Roanoke to Lowell (Indiana) | 485.61 mi (781.52 km) |
| Roanoke to Lowell (Massachusetts) | 588.00 mi (946.29 km) |
| Roanoke to Lower Burrell (Pennsylvania) | 228.61 mi (367.92 km) |
| Roanoke to Lowes Island (Virginia) | 186.99 mi (300.93 km) |
| Roanoke to Lubbock (Texas) | 1,258.08 mi (2,024.68 km) |
| Roanoke to Lufkin (Texas) | 936.63 mi (1,507.36 km) |
| Roanoke to Luling (Louisiana) | 785.05 mi (1,263.41 km) |
| Roanoke to Lumberton (North Carolina) | 190.31 mi (306.27 km) |
| Roanoke to Lumberton (Texas) | 949.84 mi (1,528.61 km) |
| Roanoke to Lutz (Florida) | 647.72 mi (1,042.41 km) |
| Roanoke to Lynbrook (New York) | 410.28 mi (660.28 km) |
| Roanoke to Lynchburg (Virginia) | 42.98 mi (69.16 km) |
| Roanoke to Lynden (Washington) | 2,255.33 mi (3,629.60 km) |
| Roanoke to Lyndhurst (Ohio) | 304.09 mi (489.38 km) |
