| Roanoke to Isabela (Puerto Rico) | 1,515.50 mi (2,438.96 km) |
| Roanoke to Iselin (New Jersey) | 378.88 mi (609.74 km) |
| Roanoke to Isla Vista (California) | 2,227.11 mi (3,584.19 km) |
| Roanoke to Issaquah (Washington) | 2,230.15 mi (3,589.08 km) |
| Roanoke to Ithaca (New York) | 401.11 mi (645.52 km) |
| Roanoke to Ives Estates (Florida) | 781.92 mi (1,258.38 km) |
| Roanoke to Jackson (Michigan) | 416.29 mi (669.96 km) |
| Roanoke to Jackson (Mississippi) | 674.74 mi (1,085.89 km) |
| Roanoke to Jackson (Missouri) | 532.41 mi (856.84 km) |
| Roanoke to Jackson (Tennessee) | 505.67 mi (813.80 km) |
| Roanoke to Jackson (Wyoming) | 1,667.08 mi (2,682.91 km) |
| Roanoke to Jacksonville (Alabama) | 404.41 mi (650.84 km) |
| Roanoke to Jacksonville (Arkansas) | 699.06 mi (1,125.02 km) |
| Roanoke to Jacksonville (Florida) | 489.93 mi (788.47 km) |
| Roanoke to Jacksonville (Illinois) | 580.33 mi (933.96 km) |
