| Roanoke to Indianapolis (Indiana) | 376.26 mi (605.53 km) |
| Roanoke to Indianola (Iowa) | 779.07 mi (1,253.80 km) |
| Roanoke to Indio (California) | 2,042.50 mi (3,287.08 km) |
| Roanoke to Inglewood (California) | 2,153.49 mi (3,465.71 km) |
| Roanoke to Inkster (Michigan) | 389.56 mi (626.94 km) |
| Roanoke to Inver Grove Heights (Minnesota) | 857.19 mi (1,379.51 km) |
| Roanoke to Inwood (New York) | 405.57 mi (652.69 km) |
| Roanoke to Iona (Florida) | 752.77 mi (1,211.47 km) |
| Roanoke to Ionia (Michigan) | 477.32 mi (768.18 km) |
| Roanoke to Iowa City (Iowa) | 686.58 mi (1,104.94 km) |
| Roanoke to Irmo (South Carolina) | 230.21 mi (370.48 km) |
| Roanoke to Irondale (Alabama) | 457.01 mi (735.48 km) |
| Roanoke to Ironton (Ohio) | 171.71 mi (276.35 km) |
| Roanoke to Irvine (California) | 2,128.05 mi (3,424.77 km) |
| Roanoke to Irving (Texas) | 1,007.67 mi (1,621.69 km) |
