| Roanoke to Enterprise (Nevada) | 1,945.89 mi (3,131.61 km) |
| Roanoke to Enumclaw (Washington) | 2,226.38 mi (3,583.02 km) |
| Roanoke to Ephrata (Pennsylvania) | 285.71 mi (459.81 km) |
| Roanoke to Erie (Colorado) | 1,362.03 mi (2,191.97 km) |
| Roanoke to Erie (Pennsylvania) | 334.34 mi (538.07 km) |
| Roanoke to Erlanger (Kentucky) | 278.48 mi (448.17 km) |
| Roanoke to Escanaba (Michigan) | 691.13 mi (1,112.26 km) |
| Roanoke to Escondido (California) | 2,101.21 mi (3,381.57 km) |
| Roanoke to Española (New Mexico) | 1,445.64 mi (2,326.53 km) |
| Roanoke to Essex (Maryland) | 236.29 mi (380.27 km) |
| Roanoke to Essex Junction (Vermont) | 612.77 mi (986.15 km) |
| Roanoke to Estelle (Louisiana) | 776.87 mi (1,250.25 km) |
| Roanoke to Estero (Florida) | 757.39 mi (1,218.90 km) |
| Roanoke to Euclid (Ohio) | 309.32 mi (497.81 km) |
| Roanoke to Eufaula (Alabama) | 473.94 mi (762.74 km) |
