| Roanoke to Elyria (Ohio) | 305.47 mi (491.61 km) |
| Roanoke to Emeryville (California) | 2,298.86 mi (3,699.66 km) |
| Roanoke to Emmaus (Pennsylvania) | 328.76 mi (529.09 km) |
| Roanoke to Emporia (Kansas) | 888.10 mi (1,429.26 km) |
| Roanoke to Encinitas (California) | 2,113.45 mi (3,401.27 km) |
| Roanoke to Endicott (New York) | 392.01 mi (630.88 km) |
| Roanoke to Endwell (New York) | 394.37 mi (634.68 km) |
| Roanoke to Englewood (Colorado) | 1,359.86 mi (2,188.49 km) |
| Roanoke to Englewood (Florida) | 725.70 mi (1,167.90 km) |
| Roanoke to Englewood (New Jersey) | 406.44 mi (654.11 km) |
| Roanoke to Englewood (Ohio) | 295.08 mi (474.88 km) |
| Roanoke to Enid (Oklahoma) | 990.78 mi (1,594.51 km) |
| Roanoke to Ennis (Texas) | 1,004.42 mi (1,616.46 km) |
| Roanoke to Ensley (Florida) | 626.98 mi (1,009.03 km) |
| Roanoke to Enterprise (Alabama) | 530.79 mi (854.22 km) |
