| Roanoke to El Segundo (California) | 2,157.45 mi (3,472.07 km) |
| Roanoke to El Sobrante (California) | 2,106.94 mi (3,390.79 km) |
| Roanoke to Eldersburg (Maryland) | 219.28 mi (352.89 km) |
| Roanoke to Elfers (Florida) | 646.48 mi (1,040.42 km) |
| Roanoke to Elgin (Illinois) | 552.89 mi (889.79 km) |
| Roanoke to Elizabeth (New Jersey) | 388.10 mi (624.58 km) |
| Roanoke to Elizabeth City (North Carolina) | 216.88 mi (349.04 km) |
| Roanoke to Elizabethton (Tennessee) | 141.87 mi (228.31 km) |
| Roanoke to Elizabethtown (Kentucky) | 325.77 mi (524.28 km) |
| Roanoke to Elizabethtown (Pennsylvania) | 268.74 mi (432.50 km) |
| Roanoke to Elk City (Oklahoma) | 1,089.73 mi (1,753.75 km) |
| Roanoke to Elk Grove (California) | 2,242.35 mi (3,608.72 km) |
| Roanoke to Elk Grove Village (Illinois) | 537.57 mi (865.14 km) |
| Roanoke to Elk Plain (Washington) | 2,243.67 mi (3,610.84 km) |
| Roanoke to Elk River (Minnesota) | 897.08 mi (1,443.72 km) |
