| Roanoke to Effingham (Illinois) | 483.40 mi (777.96 km) |
| Roanoke to Eggertsville (New York) | 397.67 mi (639.99 km) |
| Roanoke to Egypt Lake-Leto (Florida) | 656.72 mi (1,056.90 km) |
| Roanoke to El Cajon (California) | 2,102.46 mi (3,383.58 km) |
| Roanoke to El Campo (Texas) | 1,093.25 mi (1,759.42 km) |
| Roanoke to El Centro (California) | 2,025.85 mi (3,260.29 km) |
| Roanoke to El Cerrito (California) | 2,298.16 mi (3,698.53 km) |
| Roanoke to El Dorado (Arkansas) | 769.06 mi (1,237.68 km) |
| Roanoke to El Dorado (Kansas) | 925.43 mi (1,489.34 km) |
| Roanoke to El Dorado Hills (California) | 2,221.19 mi (3,574.65 km) |
| Roanoke to El Mirage (Arizona) | 1,830.95 mi (2,946.62 km) |
| Roanoke to El Monte (California) | 2,133.84 mi (3,434.09 km) |
| Roanoke to El Paso (Texas) | 1,546.67 mi (2,489.13 km) |
| Roanoke to El Paso de Robles (California) | 2,246.94 mi (3,616.11 km) |
| Roanoke to El Reno (Oklahoma) | 1,006.94 mi (1,620.51 km) |
