| Roanoke to Eatontown (New Jersey) | 379.84 mi (611.30 km) |
| Roanoke to Eau Claire (Wisconsin) | 794.11 mi (1,278.00 km) |
| Roanoke to Echelon (New Jersey) | 321.48 mi (517.36 km) |
| Roanoke to Eden (North Carolina) | 54.93 mi (88.40 km) |
| Roanoke to Eden Prairie (Minnesota) | 874.61 mi (1,407.55 km) |
| Roanoke to Edgewater (Florida) | 577.59 mi (929.54 km) |
| Roanoke to Edgewater (New Jersey) | 403.69 mi (649.67 km) |
| Roanoke to Edgewood (Maryland) | 247.43 mi (398.20 km) |
| Roanoke to Edgewood (Washington) | 2,240.23 mi (3,605.30 km) |
| Roanoke to Edina (Minnesota) | 872.07 mi (1,403.46 km) |
| Roanoke to Edinburg (Texas) | 1,305.97 mi (2,101.75 km) |
| Roanoke to Edmond (Oklahoma) | 974.91 mi (1,568.96 km) |
| Roanoke to Edmonds (Washington) | 2,245.33 mi (3,613.52 km) |
| Roanoke to Edwards (Colorado) | 1,446.30 mi (2,327.60 km) |
| Roanoke to Edwardsville (Illinois) | 555.42 mi (893.86 km) |
