| Roanoke to Des Plaines (Illinois) | 534.85 mi (860.75 km) |
| Roanoke to Desert Hot Springs (California) | 2,054.89 mi (3,307.02 km) |
| Roanoke to DeSoto (Texas) | 1,008.92 mi (1,623.69 km) |
| Roanoke to Destin (Florida) | 604.51 mi (972.86 km) |
| Roanoke to Destrehan (Louisiana) | 782.80 mi (1,259.79 km) |
| Roanoke to Detroit (Michigan) | 390.10 mi (627.81 km) |
| Roanoke to Diamond Bar (California) | 2,123.71 mi (3,417.78 km) |
| Roanoke to Diamond Springs (California) | 2,209.84 mi (3,556.40 km) |
| Roanoke to Dickinson (North Dakota) | 1,338.98 mi (2,154.88 km) |
| Roanoke to Dickinson (Texas) | 1,023.46 mi (1,647.10 km) |
| Roanoke to Dickson (Tennessee) | 418.93 mi (674.21 km) |
| Roanoke to Difficult Run (Virginia) | 180.92 mi (291.16 km) |
| Roanoke to Dinuba (California) | 2,163.46 mi (3,481.74 km) |
| Roanoke to Discovery Bay (California) | 2,260.86 mi (3,638.50 km) |
| Roanoke to Dix Hills (New York) | 430.55 mi (692.90 km) |
