| Roanoke to Delaware (Ohio) | 267.02 mi (429.73 km) |
| Roanoke to Delhi (California) | 2,223.84 mi (3,578.92 km) |
| Roanoke to Delray Beach (Florida) | 747.87 mi (1,203.58 km) |
| Roanoke to Deltona (Florida) | 583.08 mi (938.38 km) |
| Roanoke to Deming (New Mexico) | 1,608.91 mi (2,589.30 km) |
| Roanoke to Denison (Texas) | 964.29 mi (1,551.88 km) |
| Roanoke to Dent (Ohio) | 287.33 mi (462.41 km) |
| Roanoke to Denton (Texas) | 1,007.73 mi (1,621.79 km) |
| Roanoke to Dentsville (South Carolina) | 228.27 mi (367.36 km) |
| Roanoke to Denver (Colorado) | 1,353.45 mi (2,178.16 km) |
| Roanoke to Depew (New York) | 394.81 mi (635.39 km) |
| Roanoke to Derby (Connecticut) | 461.62 mi (742.91 km) |
| Roanoke to Derby (Kansas) | 948.04 mi (1,525.72 km) |
| Roanoke to Des Moines (Iowa) | 785.61 mi (1,264.31 km) |
| Roanoke to Des Moines (Washington) | 2,242.19 mi (3,608.46 km) |
