| Roanoke to Cullman (Alabama) | 441.34 mi (710.27 km) |
| Roanoke to Culpeper (Virginia) | 134.85 mi (217.02 km) |
| Roanoke to Culver City (California) | 2,155.35 mi (3,468.69 km) |
| Roanoke to Cumberland (Maryland) | 176.33 mi (283.78 km) |
| Roanoke to Cupertino (California) | 2,293.62 mi (3,691.22 km) |
| Roanoke to Cutler Bay (Florida) | 808.83 mi (1,301.69 km) |
| Roanoke to Cutlerville (Michigan) | 488.64 mi (786.39 km) |
| Roanoke to Cuyahoga Falls (Ohio) | 281.18 mi (452.52 km) |
| Roanoke to Cypress (California) | 2,139.63 mi (3,443.41 km) |
| Roanoke to Cypress Gardens (Florida) | 648.63 mi (1,043.87 km) |
| Roanoke to Cypress Lake (Florida) | 750.65 mi (1,208.05 km) |
| Roanoke to D'Iberville (Mississippi) | 695.36 mi (1,119.08 km) |
| Roanoke to Dakota Ridge (Colorado) | 1,367.36 mi (2,200.56 km) |
| Roanoke to Dale City (Virginia) | 170.85 mi (274.95 km) |
| Roanoke to Dallas (Georgia) | 359.45 mi (578.48 km) |
