| Roanoke to Cloverleaf (Texas) | 1,015.74 mi (1,634.67 km) |
| Roanoke to Cloverly (Maryland) | 204.34 mi (328.85 km) |
| Roanoke to Clovis (California) | 2,174.32 mi (3,499.22 km) |
| Roanoke to Clovis (New Mexico) | 1,312.40 mi (2,112.10 km) |
| Roanoke to Clute (Texas) | 1,057.45 mi (1,701.80 km) |
| Roanoke to Coachella (California) | 2,038.39 mi (3,280.47 km) |
| Roanoke to Coalinga (California) | 2,220.14 mi (3,572.97 km) |
| Roanoke to Coamo (Puerto Rico) | 1,561.89 mi (2,513.62 km) |
| Roanoke to Coatesville (Pennsylvania) | 291.23 mi (468.69 km) |
| Roanoke to Cockeysville (Maryland) | 235.87 mi (379.60 km) |
| Roanoke to Cocoa (Florida) | 616.47 mi (992.12 km) |
| Roanoke to Cocoa Beach (Florida) | 619.31 mi (996.68 km) |
| Roanoke to Coconut Creek (Florida) | 760.02 mi (1,223.13 km) |
| Roanoke to Coeur d'Alene (Idaho) | 1,987.57 mi (3,198.68 km) |
| Roanoke to Cohoes (New York) | 503.18 mi (809.79 km) |
