| Roanoke to Clarksdale (Mississippi) | 631.70 mi (1,016.62 km) |
| Roanoke to Clarkston (Georgia) | 339.52 mi (546.41 km) |
| Roanoke to Clarksville (Indiana) | 325.18 mi (523.33 km) |
| Roanoke to Clarksville (Tennessee) | 410.64 mi (660.86 km) |
| Roanoke to Clawson (Michigan) | 400.69 mi (644.85 km) |
| Roanoke to Clay (Alabama) | 448.48 mi (721.77 km) |
| Roanoke to Clayton (California) | 2,278.02 mi (3,666.11 km) |
| Roanoke to Clayton (Missouri) | 572.53 mi (921.39 km) |
| Roanoke to Clayton (North Carolina) | 139.80 mi (224.98 km) |
| Roanoke to Clayton (Ohio) | 296.22 mi (476.72 km) |
| Roanoke to Clearfield (Utah) | 1,727.40 mi (2,779.98 km) |
| Roanoke to Clearlake (California) | 2,301.32 mi (3,703.62 km) |
| Roanoke to Clearwater (Florida) | 662.83 mi (1,066.72 km) |
| Roanoke to Cleburne (Texas) | 1,045.09 mi (1,681.92 km) |
| Roanoke to Clemmons (North Carolina) | 89.34 mi (143.78 km) |
