| Roanoke to Channelview (Texas) | 1,012.75 mi (1,629.87 km) |
| Roanoke to Chantilly (Virginia) | 176.12 mi (283.44 km) |
| Roanoke to Chaparral (New Mexico) | 1,540.46 mi (2,479.14 km) |
| Roanoke to Chapel Hill (North Carolina) | 106.38 mi (171.20 km) |
| Roanoke to Charleston (Illinois) | 470.36 mi (756.97 km) |
| Roanoke to Charleston (South Carolina) | 308.27 mi (496.12 km) |
| Roanoke to Charleston (West Virginia) | 117.53 mi (189.15 km) |
| Roanoke to Charlotte (North Carolina) | 151.07 mi (243.12 km) |
| Roanoke to Charlottesville (Virginia) | 96.11 mi (154.68 km) |
| Roanoke to Chaska (Minnesota) | 879.66 mi (1,415.68 km) |
| Roanoke to Chatham (Illinois) | 551.64 mi (887.77 km) |
| Roanoke to Chattanooga (Tennessee) | 332.23 mi (534.67 km) |
| Roanoke to Cheat Lake (West Virginia) | 165.12 mi (265.74 km) |
| Roanoke to Chelsea (Alabama) | 464.67 mi (747.81 km) |
| Roanoke to Chelsea (Massachusetts) | 590.44 mi (950.21 km) |
