| Roanoke to Candler-McAfee (Georgia) | 345.04 mi (555.29 km) |
| Roanoke to Caño Martin Peña (Puerto Rico) | 1,550.74 mi (2,495.68 km) |
| Roanoke to Cañon City (Colorado) | 1,376.08 mi (2,214.58 km) |
| Roanoke to Canóvanas (Puerto Rico) | 1,559.35 mi (2,509.54 km) |
| Roanoke to Canton (Georgia) | 329.21 mi (529.81 km) |
| Roanoke to Canton (Illinois) | 587.15 mi (944.92 km) |
| Roanoke to Canton (Mississippi) | 655.32 mi (1,054.63 km) |
| Roanoke to Canton (Ohio) | 255.30 mi (410.87 km) |
| Roanoke to Canyon (Texas) | 1,232.79 mi (1,983.98 km) |
| Roanoke to Canyon Lake (California) | 2,099.78 mi (3,379.27 km) |
| Roanoke to Canyon Lake (Texas) | 1,168.40 mi (1,880.36 km) |
| Roanoke to Cape Coral (Florida) | 744.34 mi (1,197.89 km) |
| Roanoke to Cape Girardeau (Missouri) | 527.54 mi (848.99 km) |
| Roanoke to Carbondale (Illinois) | 508.61 mi (818.53 km) |
| Roanoke to Carlisle (Pennsylvania) | 250.54 mi (403.20 km) |
