| Roanoke to Tampa (Florida) | 657.50 mi (1,058.14 km) |
| Roanoke to Miami (Florida) | 794.33 mi (1,278.35 km) |
| Roanoke to Minneapolis (Minnesota) | 870.95 mi (1,401.66 km) |
| Roanoke to Dallas (Texas) | 998.48 mi (1,606.91 km) |
| Roanoke to Houston (Texas) | 1,026.51 mi (1,652.00 km) |
| Roanoke to Denver (Colorado) | 1,353.45 mi (2,178.16 km) |
| Roanoke to Phoenix (Arizona) | 1,818.25 mi (2,926.19 km) |
| Roanoke to Las Vegas (Nevada) | 1,944.45 mi (3,129.28 km) |
| Roanoke to Riverside (California) | 2,101.90 mi (3,382.68 km) |
| Roanoke to San Diego (California) | 2,110.68 mi (3,396.81 km) |
| Roanoke to Los Angeles (California) | 2,153.69 mi (3,466.02 km) |
| Roanoke to Seattle (Washington) | 2,243.32 mi (3,610.28 km) |
| Roanoke to Portland (Oregon) | 2,256.21 mi (3,631.02 km) |
| Roanoke to San Francisco (California) | 2,308.18 mi (3,714.65 km) |
| Roanoke to Washington (District of Columbia) | 195.47 mi (314.58 km) |
| Roanoke to Baltimore (Maryland) | 229.07 mi (368.65 km) |
| Roanoke to Philadelphia (Pennsylvania) | 321.38 mi (517.20 km) |
| Roanoke to Atlanta (Georgia) | 349.23 mi (562.03 km) |
| Roanoke to Detroit (Michigan) | 390.10 mi (627.81 km) |
| Roanoke to Brooklyn (New York) | 397.91 mi (640.38 km) |
| Roanoke to New York (New York) | 400.70 mi (644.86 km) |
| Roanoke to Queens (New York) | 408.37 mi (657.20 km) |
| Roanoke to Chicago (Illinois) | 518.01 mi (833.66 km) |
| Roanoke to St. Louis (Missouri) | 567.89 mi (913.93 km) |
| Roanoke to Boston (Massachusetts) | 585.24 mi (941.86 km) |
