| Rio Grande City to Yonkers (New York) | 1,742.43 mi (2,804.16 km) |
| Rio Grande City to Yorba Linda (California) | 1,242.85 mi (2,000.17 km) |
| Rio Grande City to York (Pennsylvania) | 1,577.77 mi (2,539.18 km) |
| Rio Grande City to Yorktown (Indiana) | 1,221.89 mi (1,966.45 km) |
| Rio Grande City to Yorkville (Illinois) | 1,208.89 mi (1,945.52 km) |
| Rio Grande City to Youngstown (Ohio) | 1,451.81 mi (2,336.46 km) |
| Rio Grande City to Youngsville (Louisiana) | 488.18 mi (785.65 km) |
| Rio Grande City to Ypsilanti (Michigan) | 1,393.15 mi (2,242.06 km) |
| Rio Grande City to Yuba City (California) | 1,584.64 mi (2,550.23 km) |
| Rio Grande City to Yucaipa (California) | 1,207.18 mi (1,942.76 km) |
| Rio Grande City to Yucca Valley (California) | 1,176.43 mi (1,893.29 km) |
| Rio Grande City to Yukon (Oklahoma) | 634.55 mi (1,021.21 km) |
| Rio Grande City to Yulee (Florida) | 1,086.72 mi (1,748.90 km) |
| Rio Grande City to Yuma (Arizona) | 1,037.41 mi (1,669.55 km) |
| Rio Grande City to Zachary (Louisiana) | 550.88 mi (886.55 km) |
