| Rio Grande City to University Place (Washington) | 1,932.57 mi (3,110.17 km) |
| Rio Grande City to Upland (California) | 1,242.28 mi (1,999.26 km) |
| Rio Grande City to Upper Arlington (Ohio) | 1,306.77 mi (2,103.04 km) |
| Rio Grande City to Upper Grand Lagoon (Florida) | 837.26 mi (1,347.44 km) |
| Rio Grande City to Upper Montclair (New Jersey) | 1,723.69 mi (2,774.02 km) |
| Rio Grande City to Urbana (Illinois) | 1,127.98 mi (1,815.32 km) |
| Rio Grande City to Urbana (Maryland) | 1,527.77 mi (2,458.70 km) |
| Rio Grande City to Urbana (Ohio) | 1,283.77 mi (2,066.02 km) |
| Rio Grande City to Urbandale (Iowa) | 1,092.51 mi (1,758.22 km) |
| Rio Grande City to Utica (New York) | 1,757.57 mi (2,828.53 km) |
| Rio Grande City to Uvalde (Texas) | 204.38 mi (328.91 km) |
| Rio Grande City to Vacaville (California) | 1,577.16 mi (2,538.20 km) |
| Rio Grande City to Vadnais Heights (Minnesota) | 1,329.16 mi (2,139.07 km) |
| Rio Grande City to Vail (Arizona) | 814.48 mi (1,310.78 km) |
| Rio Grande City to Valdosta (Georgia) | 990.95 mi (1,594.78 km) |
