| Rio Grande City to Superior (Colorado) | 1,004.89 mi (1,617.22 km) |
| Rio Grande City to Superior (Wisconsin) | 1,451.15 mi (2,335.41 km) |
| Rio Grande City to Surprise (Arizona) | 957.39 mi (1,540.77 km) |
| Rio Grande City to Susanville (California) | 1,580.16 mi (2,543.02 km) |
| Rio Grande City to Sussex (Wisconsin) | 1,302.03 mi (2,095.42 km) |
| Rio Grande City to Suwanee (Georgia) | 1,026.30 mi (1,651.66 km) |
| Rio Grande City to Swansea (Illinois) | 984.88 mi (1,585.00 km) |
| Rio Grande City to Sweetwater (Florida) | 1,144.48 mi (1,841.87 km) |
| Rio Grande City to Sweetwater (Texas) | 431.36 mi (694.21 km) |
| Rio Grande City to Sycamore (Illinois) | 1,222.52 mi (1,967.46 km) |
| Rio Grande City to Sylacauga (Alabama) | 886.62 mi (1,426.88 km) |
| Rio Grande City to Sylvania (Ohio) | 1,363.21 mi (2,193.87 km) |
| Rio Grande City to Syosset (New York) | 1,755.29 mi (2,824.87 km) |
| Rio Grande City to Syracuse (New York) | 1,717.05 mi (2,763.32 km) |
| Rio Grande City to Syracuse (Utah) | 1,266.31 mi (2,037.93 km) |
