| Rio Grande City to Storm Lake (Iowa) | 1,142.11 mi (1,838.05 km) |
| Rio Grande City to Storrs (Connecticut) | 1,844.15 mi (2,967.87 km) |
| Rio Grande City to Stoughton (Wisconsin) | 1,264.45 mi (2,034.94 km) |
| Rio Grande City to Stow (Ohio) | 1,423.63 mi (2,291.11 km) |
| Rio Grande City to Streamwood (Illinois) | 1,237.68 mi (1,991.86 km) |
| Rio Grande City to Streator (Illinois) | 1,167.34 mi (1,878.65 km) |
| Rio Grande City to Streetsboro (Ohio) | 1,429.97 mi (2,301.32 km) |
| Rio Grande City to Strongsville (Ohio) | 1,414.25 mi (2,276.01 km) |
| Rio Grande City to Stuart (Florida) | 1,146.14 mi (1,844.53 km) |
| Rio Grande City to Stuarts Draft (Virginia) | 1,403.89 mi (2,259.34 km) |
| Rio Grande City to Sturgis (Michigan) | 1,309.10 mi (2,106.79 km) |
| Rio Grande City to Suamico (Wisconsin) | 1,395.84 mi (2,246.38 km) |
| Rio Grande City to Sudley (Virginia) | 1,502.52 mi (2,418.08 km) |
| Rio Grande City to Suffern (New York) | 1,735.15 mi (2,792.46 km) |
| Rio Grande City to Suffolk (Virginia) | 1,482.70 mi (2,386.17 km) |
