| Rio Grande City to Stephenville (Texas) | 404.70 mi (651.31 km) |
| Rio Grande City to Sterling (Colorado) | 1,015.21 mi (1,633.82 km) |
| Rio Grande City to Sterling (Illinois) | 1,184.70 mi (1,906.59 km) |
| Rio Grande City to Sterling (Virginia) | 1,514.01 mi (2,436.57 km) |
| Rio Grande City to Sterling Heights (Michigan) | 1,430.74 mi (2,302.55 km) |
| Rio Grande City to Steubenville (Ohio) | 1,420.32 mi (2,285.79 km) |
| Rio Grande City to Stevens Point (Wisconsin) | 1,355.64 mi (2,181.69 km) |
| Rio Grande City to Stevenson Ranch (California) | 1,298.50 mi (2,089.73 km) |
| Rio Grande City to Stillwater (Minnesota) | 1,332.48 mi (2,144.42 km) |
| Rio Grande City to Stillwater (Oklahoma) | 681.54 mi (1,096.83 km) |
| Rio Grande City to Stockbridge (Georgia) | 1,001.88 mi (1,612.37 km) |
| Rio Grande City to Stockton (California) | 1,533.71 mi (2,468.27 km) |
| Rio Grande City to Stone Ridge (Virginia) | 1,504.40 mi (2,421.09 km) |
| Rio Grande City to Stonecrest (Georgia) | 1,011.44 mi (1,627.76 km) |
| Rio Grande City to Stony Brook (New York) | 1,775.57 mi (2,857.51 km) |
